EFFECT OF VITAMIN D DEFICIENCY IN CHRONIC RHINOSINUSITIS WITH NASAL POLYPOSIS: CLINICAL, LABORATORY & IMMUNOHISTOCHEMICAL STUDY

Abstract

Nasal polyposis is a common nasal disease with a high rate of recurrence. The pathogenesis of nasal polyposis is still unclear, but the disease is believed to be a manifestation of complex inflammatory reactions. Despite many pharmacological treatments, in most cases the outcomes are unsatisfactory and recurrences require surgery. At present, steroids in a long term topical and oral forms are the primary in the therapy for nasal polyposis. Due to well-known side effects related to steroid intake, this therapeutic option is often rejected. All of these factors indicate the need for the investigation of new agents suitable for treating nasal polyposis. Vitamin D (VD) and its different analogues, besides their classic role as regulators of calcium and phosphor homeostasis, have emerged as a large family of antiproliferative agents. Such properties suggested vitamin D potential as a therapy for chronic inflammatory diseases.