PLASMA ALDOSTERONE AND VASOPRESSIN LEVELS IN NEWBORNS OF MOTHERS WITH PREGNANCY-INDUCED HYPERTENSION

Abstract

Pregnancies complicated by hypertension are associated with increased risk of adverse fetal outcome, in addition to a number of physiological responses that might affect the fetal honnonal profile including aldosterone and vasopressin and also several hematological complications. This study was done on 72 newborns, 49 of them were born to mothers with pregnancy induced hypertension as a study group and 23 were healthy newborns to healthy mothers as a control group. We observed that 34% of the newborn ofPIH mothers were pretenn and 22.4% suffered from TIJGR and 6% of them had RDS. 95% of these newborns had their blood pressure below 95u' percentile and 2% above 95th percentile. The aldosterone level was significantly lower in the study group than those of the control group (111.59 + 39.48 ng/dl versus 145.41 + 54.59 ng/dl) and was also significantly lower in newborns to mothers with preeclampsia than control group or PIH motl1ers per se (108.4 + 36.46 ng/dl) (145.41 ± 54.59 ng/dl) (115.83 :L 43.75 ng/dl) and tl1e mean aldosterone level was significantly lower in treated group when compared to non treated and control groups.