Apoptosis in Haemopoiesis and Haematological Malignancies

Abstract

Apoptosis is an integral part of normal haemopoiesi both--a_---developmenta_l phenomenon and means o

homeostasis. In this the stromal environment and cytokine help regulate the intrinsic death program as well a providing proliferative, differentiation signals.

Apoptosis or programmed cell death has recentl

become recognized as an

important physiologica

mechanism for regulation of cell growth, development an< plays a central role in embryogenesis, morphogenesis an< regulation of normal cell tumover in multicellular organism

One of the important feature of apoptosis is that i result in elimination of dying cell without induction of a inflammatory response. In contrast, necrotic cell death i associated with loss of cell membrane integrity, resulting i: leakage of cytoplasmic contents and the induction .of a inflammatory response.

Variable apoptotic rates are also likely to regulate th homeostasis of proliferating tissue and thus participate i the control of hemopoisis and changes in response t apoptosis have clearly linked to oncogenesis.