Subclinical Peripheral Nerve Affection in Hypothyroidism
Mai Abdel Azeem Abdel Azeem Rabie;
Abstract
SUMMARY
H
ypothyroidism affects all systems in the body including the peripheral nervous system.
Common systemic manifestations including fatigue, constipation, cold intolerance, weight gain, hair loss, dry skin, irregular menstrual periods and hoarseness (Tintinalli, 2011).
Diagnosis of hypothyroidism is based on elevated (TSH) with or without low free (T4) concentration, with or without low free (T3) concentration (Dayan, 2001).
The existence of hypothyroid neuropathy is a point of debate and its pathogenesis is incompletely understood. Variable pathologic mechanisms were described including mucopolysaccharide-protein complexes within nerves, reduction in the myelinated fibers with segmental demyelination and remyelination, aggregates of glycogen granules, mitochondria, lipid droplets and lamellar bodies leading to axonal degeneration, and disruption of neurotubules and neurofilaments (Waghmare et al., 2015).
H
ypothyroidism affects all systems in the body including the peripheral nervous system.
Common systemic manifestations including fatigue, constipation, cold intolerance, weight gain, hair loss, dry skin, irregular menstrual periods and hoarseness (Tintinalli, 2011).
Diagnosis of hypothyroidism is based on elevated (TSH) with or without low free (T4) concentration, with or without low free (T3) concentration (Dayan, 2001).
The existence of hypothyroid neuropathy is a point of debate and its pathogenesis is incompletely understood. Variable pathologic mechanisms were described including mucopolysaccharide-protein complexes within nerves, reduction in the myelinated fibers with segmental demyelination and remyelination, aggregates of glycogen granules, mitochondria, lipid droplets and lamellar bodies leading to axonal degeneration, and disruption of neurotubules and neurofilaments (Waghmare et al., 2015).
Other data
| Title | Subclinical Peripheral Nerve Affection in Hypothyroidism | Authors | Mai Abdel Azeem Abdel Azeem Rabie | Issue Date | 2017 |
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