Evaluation of MicroRNA-93 and miRNA-210 in Egyptian Patient with Post HCV Hepatocellular Carcinoma

Abstract

SUMMARY H epatocellular carcinoma (HCC) is one of the most deadly malignancies worldwide HCC, the major type of liver cancer, is the fifth most frequent neoplasm and the third most common cause of cancer-related death in the world. HCC incidence has doubled in Egypt in the past 10 years, which could be attributed to the high prevalence of hepatitis C virus (HCV) and hepatitis B virus (HBV). The prognosis of patients with HCC remains extremely poor. Treatment of HCC presents a significant challenge because detection of such tumors usually occurs at advanced stage or after metastasis so early detection is the best choice. Current diagnosis of HCC relies on clinical information, liver imaging and measurement of serum alpha-fetoprotein (AFP). These methods are not sufficient for early diagnosis and so additional markers are needed.