Hypoglycemic and Hypolipidemic Effect of Dietary Supplementation of Plantagopsyllium Seeds on Diabetic Rats Fed High Cholesterol Diet

Abstract

Diabetes mellitus (DM) is a metabolic disorder of multiple etiologies characterized by chronic hyperglycemia with disturbances of carbohydrates, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. The effects of DM include long term damage, dysfunction and failure of various organs. In its most sever forms, ketoacidosis or a non- ketotic hyperosmolar state may develop and lead to coma and in absence of effective treatment, death. The long term effect of DM include progressive development of the specific complication of retinopathy with potential blindness, nephropathy that may lead to renal failure, and /or neuropathy with risk of foot ulcers ,amputation, and features of autonomic dysfunction, including sexual dysfunction .People with diabetes are at increased risk of cardiovascular, peripheral vascular and cerebrovascular disease. Hyperlipidemia is a medical condition characterized by an elevation of any or all lipid profile and/or lipoproteins in the blood. One of the most common diabetic complications is hyperlipidemia. It is also called