(EVALUATION OF TREATMENT RESULTS AND ROLE OF RADIOTHERAPY IN ADVANCED STAGE HODGKIN'S DISEASE (III & IV

Abstract

This study included 169 patients, 79 cases of pediatric and 90 cases of adults with advanced stage Hodgkin's disease (stage III and IV) treated at Radiation Oncology Department, NCI, Cairo University during the period between January 1990 to December 1996.

The median age in children was 9.5 years and in adults was

34 years. The male to female ratio was 5.6:1 in pediatric and 3.5:1 in adults. According to Ann Arbor staging system, 70 patients had stage III and 9 had stage IV in pediatric while in adults 74 patients . had stage III and 16 patients had stage IV. Unfortunately, 37 patients lost follow up, , and they were excluded from treatment results and survival analysis. According to Rye classification, the mixed cellularity and nodular sclerosis were the most frequent pathological subtypes encountered in the present study .

The main line of treatment was chemotherapy using ABVD, C.MOPP or alternating ABVD & C.MOPP in adults and COPP/OPPA, C.MOPP or E.COP/E. OPA in pediatric. Complete remission was 60.7% in pediatric and 57.7% in adults and after addition of radiotherapy the complete remission rate was raised to 90.2% in pediatric and 90.I% in adults.