Proinflammatory cytokines and adhesion molecules in acute myocardial infarction diagnostic role and prognostic implications
Al-Sayed Gaber Aly;
Abstract
Objectives: To study the cardiac inflammatory responses namely release of cytokines IL-lB, IL-6, IL-8 and TNF-a and expression of adhesion molecule ICAM-1 in reperfused acute MI treated by thrombolytic therapy in comparison with acute Ml not subjected to thrombolysis and normal volunteers.
Design: Prospective study:
Patients: 60 patients with acute Ml (group I, 30 patients treated with thrombolytic therapy, group II, 30 patients not subjected to thrombolysis. Patients in group I were further subclassified into group lA who showed successful thrombolysis and group IB who failed to achieve a successful thrombolysis) together with 20 healthy controls.
Metltod'>: Serial blood samples were obtained immediately on admission, 6 hrs and 24 hrs later for estimation of plasma cytokines level (IL-IB, IL-6, IL-8 and TNF-o:) and measurement of soluble ICAM-1, left ventricular function was assessed by transthoracic echocardiography and vessel patency by coronary angiography.
Results: In general it was observed that except for !L-IB, all other cytokines levels plus level of adhesion molecule ICAM•l were more elevated in patients treated with successful thrombolysis (Group lA) if compared to patients not receiving thrombolytic therapy (Group II) or the trial was not successful (Group IB). Elevation of plasma levels of different cytokines (IL-6, IL-8 and TNF-a) and adhesion molecule (!CAM-I) was observed at 6hrs after admission.and 24hrs later. It was also observed that, plasma level of IL-6, IL-8 and TNF-a and !CAM-I were more elevated with significant difference in patients with complicated course by left ventricular failure when compai-ed to those who passed smooth course_ Moreover regression analysis between EF"/o and these cytokines and !CAM-I showed that with more higher levels of these cytokines and ICAM•l there was more lower EP'/o.
Conclusion: Besides their role in neutrophil mediated injury ofmyocytes in acute Ml, the cytokines IL-6, IL-8 and TNF-a and adhesion molecule !CAM- I can serve as markers of successful reperfusion and predictors of left ventricular function deterioration.
Design: Prospective study:
Patients: 60 patients with acute Ml (group I, 30 patients treated with thrombolytic therapy, group II, 30 patients not subjected to thrombolysis. Patients in group I were further subclassified into group lA who showed successful thrombolysis and group IB who failed to achieve a successful thrombolysis) together with 20 healthy controls.
Metltod'>: Serial blood samples were obtained immediately on admission, 6 hrs and 24 hrs later for estimation of plasma cytokines level (IL-IB, IL-6, IL-8 and TNF-o:) and measurement of soluble ICAM-1, left ventricular function was assessed by transthoracic echocardiography and vessel patency by coronary angiography.
Results: In general it was observed that except for !L-IB, all other cytokines levels plus level of adhesion molecule ICAM•l were more elevated in patients treated with successful thrombolysis (Group lA) if compared to patients not receiving thrombolytic therapy (Group II) or the trial was not successful (Group IB). Elevation of plasma levels of different cytokines (IL-6, IL-8 and TNF-a) and adhesion molecule (!CAM-I) was observed at 6hrs after admission.and 24hrs later. It was also observed that, plasma level of IL-6, IL-8 and TNF-a and !CAM-I were more elevated with significant difference in patients with complicated course by left ventricular failure when compai-ed to those who passed smooth course_ Moreover regression analysis between EF"/o and these cytokines and !CAM-I showed that with more higher levels of these cytokines and ICAM•l there was more lower EP'/o.
Conclusion: Besides their role in neutrophil mediated injury ofmyocytes in acute Ml, the cytokines IL-6, IL-8 and TNF-a and adhesion molecule !CAM- I can serve as markers of successful reperfusion and predictors of left ventricular function deterioration.
Other data
| Title | Proinflammatory cytokines and adhesion molecules in acute myocardial infarction diagnostic role and prognostic implications | Other Titles | السيتوكينات والجزيئات اللاصقة فى مرض احتشاء عضلة القلب الدور التشخيصى والتوقعى | Authors | Al-Sayed Gaber Aly | Keywords | .Cytokines. lnterleukin-IB. lnterleukin-6. lnterleukin-8. Tumor necrosis factor-a. Adhesion molecules. Intercellular adhesion molecule-!(ICAM-1). Acute myocardial infarction. Reperfusion injury | Issue Date | 2000 |
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