The Protective Effect of Green Tea and Garlic on the Pancreas of Albino Rat in Cases of Induced Diabetes Mellitus

Abstract

Diabetes mellitus is a common metabolic disorder associated with degenerative changes in the pancreas. Due to its high prevalence and marked effects on a patient physical and psychological state, diabetes mellitus, which can result in a morbid condition, is a major medical concern. Moreover, Alloxan is the most widely used drug for induction of diabetes mellitus in laboratory rats .Single intra-peritoneal administration of 180 mg ∕ Kg alloxan leads to a condition closely resembling human type1 diabetes mellitus. Many alternative medicines were studied to be used in the treatment of diabetes mellitus, beside or instead of the traditional treatment of diabetes with oral hypoglycemic drugs and insulin injections. Green tea and garlic were used nowadays as anti-diabetic agents depending on their powerful hypoglycemic action. So, the aim of the present work is to study the histological, ultra structural and biochemical effects of green tea and garlic on the pancreatic tissue to asses their use in the treatment of diabetes mellitus.