ANTIMUTAGbJVIC ACTIVITY OF SEVERAL NATURAL PRODUCTS IN THE METABOLIC ACTIVITY OFHETEROCYCLIC AMJNES
Asmaa Abu Bakr El-Seddik Mohamed;
Abstract
The present study deals with antimutagenic activity of some natural products which are : Nigella sativa extract, garlic powder, and sesame oil.
This study used six heterocyclic aromatic amines which are potent mutagens to evaluate the antimutagenic activity of these natural compounds. These heterocyclic amines are :
1 )3-amino-1-methyi-5-H pyrido [4, 3-b] indo!, (Trp-p-2)
2)2-amino-6-methyldipyrido-[1,2-a:3', 2'-d]imidazole (Glu-p-1).
3) 2-amino-3-methyLimidazo [4, 5-f] quinoline (IQ).
4) 2-amino-3,8 dimethyLimidazo[4, 5-f] quinoxaline (MeiQx).
5) 2-A.mino fluorine (2-AF).
6) 2-acetyl amino fluorine (2-AAF).
Ames technique was used to estimate the mutagenic activity of these heterocyclic aromatic amines which depends on special strain of bacteria (Salmonella typhimurium TA 98) in the presence of mammalian liver microsomes.
This study used six heterocyclic aromatic amines which are potent mutagens to evaluate the antimutagenic activity of these natural compounds. These heterocyclic amines are :
1 )3-amino-1-methyi-5-H pyrido [4, 3-b] indo!, (Trp-p-2)
2)2-amino-6-methyldipyrido-[1,2-a:3', 2'-d]imidazole (Glu-p-1).
3) 2-amino-3-methyLimidazo [4, 5-f] quinoline (IQ).
4) 2-amino-3,8 dimethyLimidazo[4, 5-f] quinoxaline (MeiQx).
5) 2-A.mino fluorine (2-AF).
6) 2-acetyl amino fluorine (2-AAF).
Ames technique was used to estimate the mutagenic activity of these heterocyclic aromatic amines which depends on special strain of bacteria (Salmonella typhimurium TA 98) in the presence of mammalian liver microsomes.
Other data
| Title | ANTIMUTAGbJVIC ACTIVITY OF SEVERAL NATURAL PRODUCTS IN THE METABOLIC ACTIVITY OFHETEROCYCLIC AMJNES | Other Titles | نشاط بعض المركبات الطبيعية كمضادات لعملية التطفير التى يحدثها التنشيط الايضى لبعض الامينات الحلقية غير المتجانسة | Authors | Asmaa Abu Bakr El-Seddik Mohamed | Issue Date | 1998 |
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