SERUM LEPTIN CONCENTRATION IN CHRONIC RENAL FAILURE PATIENTS WITH OR WITHOUT HAEMODIALYS

Abstract

In patients with CRF, protein caloric malnutrition is a common problem. It was associated with increased morbidity and mortality. Numerous factors contribute to malnutrition but decreased food intake due to anorexia is probably the most important (Stenvinkel et al ., 1999). The present study was aimed to study serum leptin concentration m patients with CRF under different modalities of treatment and to study the relationship between serum leptin and nutritional parameters, anorexia and anemia in these patients . The study included 60 patients with CRF classified into three groups: 20 under haemodialysis, 20 under peritoneal dialysis and 20 under conservative treatments. It also included 20 healthy subjects served as controls. Full clinical history, complete clinical examination, anthropometric measurments including (BMI , TSFT and WHR) and abdominal U.S. were done to all studied subjects. The following laboratory investigation were also made to all subjects: I- Routine investigations included fasting blood glucose, serum albumin, serum urea, serum creatinine, creatinine clearance , serum uric acid , serum electrolytes (Na+, K+, Ca++ & ph.), and complete blood picture.