A STUDY ON TOTAL ANTIOXIDANT STATUS AND LIPID PEROXIDATION IN MULTI-TRAUMATIZED CRITICALLY- ILL PATIENTS

Abstract

Generation of ROS and oxidative stress were reported to play a significant role in the pathogenesis of tissue damage in many conditions including trauma. The present study has been performed to study the occurrence and time course of oxidative stress, as appreciated through the measurement of serum antioxidant capacity and MDA concentration, in multi-trauma patients and its correlation with the injury severity, surgical interference, and post-traumatic complications as sepsis, MOD syndrome and non-survival. The study was performed on 30 multi-traumatized patients: 21 males and 9 females, in the age range of 10 to 55 years. Co-morbid conditions were excluded by: thorough history taking, clinical examination and laboratory investigations. The patients were evaluated on admission by the anatomical injury severity score (ISS) and the physiological trauma score (TS), and were followed up by the multi-organ dysfunction score (MOD score) at 24 hours, 3 days, 5 days and 7 days after admission. The serum TAO capacity and MDA concentrations were measured

on admission, and at 6 hours, 24 hours, 3 days, 5 days and 7 days after admission. The obtained values were related to total serum proteins to avoid false low results due to the effect of blood dilution (by any fluid therapy). The results were compared with results obtained from a healthy control group of comparable age and sex distribution.