Gene Polymorphism of Nitric Oxide Synthase and Angiotensinogen in Coronary Artery Disease
Mai Nabil Mohamed;
Abstract
Coronary artery disease (CAD) is the main cause of death in western countries. It is a multifactorial and multigenic disease. Its prevalence varies among different populations. Epidemiological and familial studies have shown genetic and environmental factors cooperating in the pathogenesis of CAD.
The present study included 100 individuals classified into two groups: Fifty CAD patients
(30 male, 20 female), and fifty normal apparently healthy individuals (32 male, 18female).
Relation between atherosclerotic risk factors and studied parameters was performed. Possible associations between different studied parameters were assessed.
In the present work, the frequency of Glu298Asp polymorphism in exon 7 of the eNOS
gene and that of M235T polymorphism in exon 2 of the AGT gene was significantly higher in CAD group than in controls. However, the mean serum level of NO'was significantly lower in CAD group, while that of Ang 1 was significantly higher in CAD patients than in control subjects.
The frequency of eNOS TT homozygotes in patients with CAD was significantly higher
than that in healthy control subjects (76.9% vs. 23.1% respectively). Lack of an increased risk of CAD in the eNOS GT heterozygotes (37.8%) suggests that the increased risk is confined to eNOS TT homozygotes. However, no significant difference was observed in the frequency of mutant T allele between CAD and control groups (52.1% and 47.9% respectively).
The frequency of the mutant T allele of AGT M235T variant was significantly higher in
CAD patients than that in controls (67.1% vs. 32.9% respectively). Moreover. the frequency of AGT TT homozygotes in CAD patients was significantly higher than that in healthy control subjects (78.6% vs. 21.4% respectively).
The present study included 100 individuals classified into two groups: Fifty CAD patients
(30 male, 20 female), and fifty normal apparently healthy individuals (32 male, 18female).
Relation between atherosclerotic risk factors and studied parameters was performed. Possible associations between different studied parameters were assessed.
In the present work, the frequency of Glu298Asp polymorphism in exon 7 of the eNOS
gene and that of M235T polymorphism in exon 2 of the AGT gene was significantly higher in CAD group than in controls. However, the mean serum level of NO'was significantly lower in CAD group, while that of Ang 1 was significantly higher in CAD patients than in control subjects.
The frequency of eNOS TT homozygotes in patients with CAD was significantly higher
than that in healthy control subjects (76.9% vs. 23.1% respectively). Lack of an increased risk of CAD in the eNOS GT heterozygotes (37.8%) suggests that the increased risk is confined to eNOS TT homozygotes. However, no significant difference was observed in the frequency of mutant T allele between CAD and control groups (52.1% and 47.9% respectively).
The frequency of the mutant T allele of AGT M235T variant was significantly higher in
CAD patients than that in controls (67.1% vs. 32.9% respectively). Moreover. the frequency of AGT TT homozygotes in CAD patients was significantly higher than that in healthy control subjects (78.6% vs. 21.4% respectively).
Other data
| Title | Gene Polymorphism of Nitric Oxide Synthase and Angiotensinogen in Coronary Artery Disease | Other Titles | التحور الجيني في مخلقات أكسيد النيتريك والأنجيوتنسينوجين في أمراض الشريان التاجي | Authors | Mai Nabil Mohamed | Issue Date | 2010 |
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