PROGNOSTIC SIGNIFICANCE OF CD25 AND CD123 EXPRESSION IN ACUTE MYELOID LEUKEMIA

Abstract

In conclusion, our study revealed that CD123 was expressed in 43.3% of our AML cases, CD25 expression was detected in 13.3% of patients and so is the co-expression of CD123/CD25 (13.3%). Correlating CD123 and CD25 with known prognostic factors showed that CD123 was associated with higher TLC and BM blast percentage. CD25 was positively correlated with CD123 expression. Regarding the relation of CD123 and CD25 with cytogenetic prognostic groups, it was noted that 54.6% of CD123 positive cases and 50% of CD25 positive cases were in the intermediate cytogenetic prognostic groups. Our Study revealed the effect of CD123 on patients outcome on day 28, all positive patients had poor outcome were 8 out of 13 patients didn’t achieve hematological remission and 5 out of 13 died shortly after diagnosis. All CD25 positive cases died shortly after diagnosis noting that these cases were also CD123 positive and represents (50%) of all cases. Thus, the results of our study clearly demonstrate the poor prognostic significance of CD123 and CD25 expression in AML patients. This may represent additional prognostic tool in risk stratified management of AML patients, so these patients should be considered for stem cell transplantation and for novel investigative therapies.D