Salmonella typhimurium Treated by Radiation as an Approach for Cancer Management
Neveen Abd Elaziz Mohamed;
Abstract
The present study was planned to evaluate the efficiency of UV- and radiation as a tool to induce variant derivatives from S. typhimurium . WT. capable to prevent the solid tumor proliferation.
To achieve our goal the protocol divided into 2 sections. First, the exposure and cycling of S. typhimurium .WT. strain. Using UV and radiation to induce variants strains have different characters and to reduce its pathogenicity in mice in-vivo. Second, was testing these UV- and radiation induced variants for their antitumor activity in -vitro and in- vivo.
To fulfill the target of this study a total of 100 male mice were allocated into groups as the following:
Group 1: Control group; animals left without any treatment.
Group 2: (tumor group); animals bearing solid Ehrlich tumor left without any treatment.
Group 3: (S. typhimurium .WT.); animals not bearing solid Ehrlich tumor and injected with 100µl of S. typhimurium . WT. at dose of 1x104 cfu (i.p) and 200lµl at same dose 3 times (i.m) 4 days apart.
Group 4: (S. typhimurium . WT. + tumor); animals bearing solid Ehrlich tumor and injected with 100µl of S.
To achieve our goal the protocol divided into 2 sections. First, the exposure and cycling of S. typhimurium .WT. strain. Using UV and radiation to induce variants strains have different characters and to reduce its pathogenicity in mice in-vivo. Second, was testing these UV- and radiation induced variants for their antitumor activity in -vitro and in- vivo.
To fulfill the target of this study a total of 100 male mice were allocated into groups as the following:
Group 1: Control group; animals left without any treatment.
Group 2: (tumor group); animals bearing solid Ehrlich tumor left without any treatment.
Group 3: (S. typhimurium .WT.); animals not bearing solid Ehrlich tumor and injected with 100µl of S. typhimurium . WT. at dose of 1x104 cfu (i.p) and 200lµl at same dose 3 times (i.m) 4 days apart.
Group 4: (S. typhimurium . WT. + tumor); animals bearing solid Ehrlich tumor and injected with 100µl of S.
Other data
| Title | Salmonella typhimurium Treated by Radiation as an Approach for Cancer Management | Other Titles | السالمونيلا تيفيميوريم المعاملة بالإشعاع كوسيلة للتحكم فى السرطان | Authors | Neveen Abd Elaziz Mohamed | Issue Date | 2017 |
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