SERUM CYSTATIN C LEVEL IN EVALUATION OF RENAL FUNCTION IN PATIENTS WITH CIRRHOTIC ASCITES

Abstract

Renal dysfunction is common in patients with liver cirrhosis which occurs in about 19% of hospitalize patients with cirrhosis, so a precious assessment of renal function is required to estimate the prognosis and determine the correct therapeutic intervention and response. So this study was carried out to evaluate the advantage of serum cystatin C as a marker of renal dysfunction over the routine renal function test in cirrhotic patients and whether it has a correlation with degree of liver affection while using pughi modification of child as a marker of liver affection. The present study carried out on 50 patients with cirrhotic ascites and normal serum creatinine levels. All patients in this study are subjected to the following: 1. A full history taking. 2. A through clinical examination. 3. Liver function tests including: ALT, AST, ALP, Total protein, Albumin, Total and direct bilirubin, PT, INR. 4. Kidney function tests; serum creatinine, uric acid, BUN, Na, and K. 5. Abdominal U/S. Summary  86 G. Child TURCOH Pugh classification. 7. Serum cystatin C assay measured by ELISA. 8. Measurement of GFR by 99m Tc DTPA scan. 9. CBC and CRP. The results of this study showed and confirmed that in patients with liver cirrhosis, cystatin C level is more sensitive for detecting renal dysfunction than increased serum creatinine level. Cystati