Study of chemokine receptor CXCR3 exPression in B-chronic lymphocytic leukemia and B-cell lymphomas
Sherein Mohamed Ibrahim Shaaban;
Abstract
The control of cell migration in the immune system is mediated by several chemokines and their receptors. The chemokine receptor CXCR3 was found to be widely expressed on activated T cells.
The aim of this work was to analyze the expression of CXCR3
chemokine receptors on normal B-lymphocytes obtained from healthy donors (15 subject) and on malignant B cells from patients with B cell malignancies (20 cases ofB- CLL and 12 cases ofB- NHL).
CXCR3 expression in both B-CLL and B-NHL was higher and showed
high significance when compared with control. Positive correlations were found between CXCR3 expression and staging, white blood cell count, lymphocyte percentage and CD20.
In conclusion: Our results demonstrated that CXCR3 might be a
hallmark in B cell malignancies.
The aim of this work was to analyze the expression of CXCR3
chemokine receptors on normal B-lymphocytes obtained from healthy donors (15 subject) and on malignant B cells from patients with B cell malignancies (20 cases ofB- CLL and 12 cases ofB- NHL).
CXCR3 expression in both B-CLL and B-NHL was higher and showed
high significance when compared with control. Positive correlations were found between CXCR3 expression and staging, white blood cell count, lymphocyte percentage and CD20.
In conclusion: Our results demonstrated that CXCR3 might be a
hallmark in B cell malignancies.
Other data
| Title | Study of chemokine receptor CXCR3 exPression in B-chronic lymphocytic leukemia and B-cell lymphomas | Other Titles | دراسة تعبير مستقبل الكيموكين CXCR3 في سرطان الدم االليمفاوي – ب وسرطان الغدد الليمفاوية - ب | Authors | Sherein Mohamed Ibrahim Shaaban | Keywords | .CXCR3, Chronic lymphocytic leukemia, Non-Hodgkin lymphoma | Issue Date | 2002 |
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