Synthesis, Radiolabeling and Evaluation of some Specific Probes for Malignant Melanoma Imaging

Abstract

This chapter deals with an overview of using nuclear medicine and radiopharmaceuticals for diagnosis and treatment of human tumors disease. From all radioisotopes, radioiodine and radiofluorine are the most frequently used in the nuclear medicine. The methods used for radiolabelling are the electrophilic technique using an oxidizing agent such as chloramines–T and iodogen, and nucleophilic technique. It includes an information about human skin and types of skin cancers especially melanoma which is the most malignant one because it spread to almost every organ. It contains also a review for different compounds used before for melanoma imaging in nuclear medicine. Chapter II: Experimental and Methodology This chapter contains detailed information of the chemicals, reagents, radionuclides and equipment used in the study. It includes the synthesis of the relevant compounds and its characterization by mass and nuclear magnetic resonance spectroscopy. It involves also the labeling of benzamide derivatives by 125I using electrophilic substitution and nicotinamide derivatives by 18F. The separation and the purification of the relevant compounds were done by:- 1- Thin layer chromatography 2- High-pressure liquid chromatography Chapter III: Results and Discussion This study is divided into two parts: The first part composes of: 1. The synthesis of some benzamides derivatives, 2. Studying the parameters that affect their radiodination by 125I,