ADIPOQ GENE RS1501299 POLYMORPHISM AND TYPE 2 DIABETES MELLITUS: A PILOT STUDY

Abstract

Obesity is considered as a multifactorial condition resulting from combination between genetic, environmental and\or pathological causes leading to accumulation of excessive body fat. It is also considered as an inflammatory process which results in multiple co-morbidities as insulin resistance, coronary heart disease, cancer, hyperlipidemia and metabolic syndrome. Diabetes mellitus is stated to be a multifactorial and a polygenic syndrome. Some researchers showed that gene polymorphisms of some genes may contribute to that pathology. Insulin resistance is considered the main feature of T2DM. Adiponectin is an insulin sensitizing hormone which is secreted from adipocytes. It acts through three receptors adiponectin receptor 1, adiponectin receptor 2 and T cadherin. It has cardioprotective effects, antiatherogenic, anti-inflammatory, as well as other functions in obesity related diseases and in immunity.