Efficacy of Sugammadex in Reversal of Deep Neuromuscular block induced by Steroidal Muscle Relaxants

Abstract

Adequate reversal of neuromuscular block is an important consideration in anaesthesia. Restoration of normal neuromuscular function may occur spontaneously or may be hastened with the use of acetylcholinesterase inhibitors such as neostigmine. Acetylcholinesterase inhibitors, however, have some problems as incomplete reversal or residual block in the recovery room, and a relatively high incidence of cholinergic side effects, as bradycardia, hypotension, bronchoconstriction, vomiting etc. They are effective in reversing neuromuscular block (NMB) only if given when partial recovery of NMB is reached due to its indirect action. Muscarinic antagonists such as atropine when administered concomitantly may result in tachycardia, dry mouth and mydriasis. Safe, effective and fast reversal of skeletal muscle relaxants is a worldwide anaesthetic objective. Recovery