SPERM-OVUM INTERACTION
Ahmed Gamal Abd El Tawab;
Abstract
F
ertilization is the process by which two gametes belonging to the same species encounter each other and fuse to create a new individual. Species use different pathways to ensure that their gametes arrive correctly at the meeting point. It is very essential as it is the heart of creating life. Mature and competent gametes are needed to achieve this process.
Sperm-ovum interaction is a specialized process that leads to fertilization and activation of development. The molecular basis of human sperm ovum interaction is still not completely known.
Capacitation is one of the most important prerequisites of a successful sperm-ovum interaction, which occurs during sperm journey in the female reproductive tract and is affected by humoral factors as well as by interaction between the sperm and the oviductal epithelium. Capacitation enables spermatozoa to gain hyperactive motility, adhere to the zona pellucida, respond to physiological inducers of the acrosome reaction and initiate fusion with the oocyte.
The present assay was designed to present an overview regarding the molecular mechanisms involved in sperm ovum interaction and the components participating in this process. The process by which spermatozoa reach, recognize, bind to and fuse with the ovum.
Capcitation is initiated when the male gamete traverses the cervical mucus with the removal of inhibitory factors from the seminal plasma. Capacitaion has been associated mainly with modifications in the sperm plasma membrane composition and fluidity, changes in intracellular ion concentration, generation of low and controlled levels of reactive oxygen species and increase in protein phosphorylation.
Hyperactivation is an essential process for spermatozoa to successfully fertilize oocytes, and Calcium is a fundamental regulatory factor. Hyperactivation is associated with sperm capacitation.
Migration of the sperm towards the ovum is guided by both thermotaxis and chemotaxis. Thermotaxis is the movement of cells in the direction of a temperature gradient and chemotaxis is the directed movement of cells along a chemical concentration gradient.
ertilization is the process by which two gametes belonging to the same species encounter each other and fuse to create a new individual. Species use different pathways to ensure that their gametes arrive correctly at the meeting point. It is very essential as it is the heart of creating life. Mature and competent gametes are needed to achieve this process.
Sperm-ovum interaction is a specialized process that leads to fertilization and activation of development. The molecular basis of human sperm ovum interaction is still not completely known.
Capacitation is one of the most important prerequisites of a successful sperm-ovum interaction, which occurs during sperm journey in the female reproductive tract and is affected by humoral factors as well as by interaction between the sperm and the oviductal epithelium. Capacitation enables spermatozoa to gain hyperactive motility, adhere to the zona pellucida, respond to physiological inducers of the acrosome reaction and initiate fusion with the oocyte.
The present assay was designed to present an overview regarding the molecular mechanisms involved in sperm ovum interaction and the components participating in this process. The process by which spermatozoa reach, recognize, bind to and fuse with the ovum.
Capcitation is initiated when the male gamete traverses the cervical mucus with the removal of inhibitory factors from the seminal plasma. Capacitaion has been associated mainly with modifications in the sperm plasma membrane composition and fluidity, changes in intracellular ion concentration, generation of low and controlled levels of reactive oxygen species and increase in protein phosphorylation.
Hyperactivation is an essential process for spermatozoa to successfully fertilize oocytes, and Calcium is a fundamental regulatory factor. Hyperactivation is associated with sperm capacitation.
Migration of the sperm towards the ovum is guided by both thermotaxis and chemotaxis. Thermotaxis is the movement of cells in the direction of a temperature gradient and chemotaxis is the directed movement of cells along a chemical concentration gradient.
Other data
| Title | SPERM-OVUM INTERACTION | Other Titles | تفاعل الحيوان المنوي بالبويضة | Authors | Ahmed Gamal Abd El Tawab | Issue Date | 2014 |
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