ASSESSMENT OF ROLE OF MELATONIN AS ANTI-OXIDANT ON LEAD-INDUCED HEPATOTOXICITY IN ADULT MALE ALBINO RATS
Walaa Ahmed Moustafa Mohamed;
Abstract
The present work is an attempt to investigate the harmful effects of exposure to lead on some physiological and histochemical parameters of the liver tissue of male albino rats.
This work also evaluates the potency of melatonin in attenuating stimulated lead hazards . It is a hormone secreted from the pineal gland and plays an important role as an antioxidant . The toxic animals were treated with melatonin
( 200 or 400 )lg I Kg. b.wt) for one month reduce the hazards effects of exposure to lead .
Results were obtained from the treated experimental animal groups and compared with the corresponding normal control rat group.
The present findings were further discussed in view of relevant literature available in similar fields of studies .
The following parameters were estimated :-
Haemoglobin , iron , total iron binding capacity , unsaturated iron binding capacity , ferritin , glucose , glycogen , AST and ALT and ALP activities , serum total protein , albumin , globulin, N G ratio and alpha feto protein (AFP) as tumor
marker:
Liver of albino rats were chosen where the study involved different histological and histochemical parameters .
This work also evaluates the potency of melatonin in attenuating stimulated lead hazards . It is a hormone secreted from the pineal gland and plays an important role as an antioxidant . The toxic animals were treated with melatonin
( 200 or 400 )lg I Kg. b.wt) for one month reduce the hazards effects of exposure to lead .
Results were obtained from the treated experimental animal groups and compared with the corresponding normal control rat group.
The present findings were further discussed in view of relevant literature available in similar fields of studies .
The following parameters were estimated :-
Haemoglobin , iron , total iron binding capacity , unsaturated iron binding capacity , ferritin , glucose , glycogen , AST and ALT and ALP activities , serum total protein , albumin , globulin, N G ratio and alpha feto protein (AFP) as tumor
marker:
Liver of albino rats were chosen where the study involved different histological and histochemical parameters .
Other data
| Title | ASSESSMENT OF ROLE OF MELATONIN AS ANTI-OXIDANT ON LEAD-INDUCED HEPATOTOXICITY IN ADULT MALE ALBINO RATS | Other Titles | تقييم دور الميلاتونين كمضاد للأكسدة علي سمية الكبد المحدث بالرصاص في ذكور الجرذان البيضاء البالغة | Authors | Walaa Ahmed Moustafa Mohamed | Issue Date | 2002 |
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