DIAGNOSTIC VALUE OF URINARY RETINOL BINDING PROTEIN IN CHILDHOOD NEPHROTIC SYNDROME
NAHLA AHMED EL MARAKBY;
Abstract
The term nephrotic syndrome refers to a classic tetrad of proteinuria, hypoproteinemia, edema and hypL'riipidcmia.
This disease is one of the most common renal diseases in
childhood. It is a disease of m jor concern as it causes signi I]cant morbidity for children, and anxiety fiJr families and considerable consumption of medical resources.
The etiology of INS is not entirely clear, early success in controlling nephrosis with immunosuppressive drugs suggested that the disease was mediated immunologically .
Although renal biopsy is the dcllnitivc investigation in kidney disorders and is particularly helpful in distinguishing steroid responsive ncphn>tic syndrome J"rom li>cal glomerulosclerosis. It is al\cndcd hy a small risk lor patients. Over the past three decades many attempts have been made to develop reliable non-invasive tests to predict underlying
kidney disorders and response to steroids.
Our study was done to evaluate the diagnostic value or urinary
level of retinol binding protein as an indicator li>r steroid response
Our study was carried out on i' patients suiTering ti•om NS attending the nephrology clinic in the Children Hospital, Cairo University. these patients were divided into two groups, the l(mnar gnJUp was steroid sensitive and the later group was steroid resistant. The study included also \ • healthy children with same age as a control group.
The results o(our studr showetl that:
Renal tubular markers as retinol binding protein can he used as sensitive diagnostic and prognostic tests in detection of steroid response.
It was found that RBI' is elevated in steroid reSIStant patients and low in steroid sensitive patients.
This disease is one of the most common renal diseases in
childhood. It is a disease of m jor concern as it causes signi I]cant morbidity for children, and anxiety fiJr families and considerable consumption of medical resources.
The etiology of INS is not entirely clear, early success in controlling nephrosis with immunosuppressive drugs suggested that the disease was mediated immunologically .
Although renal biopsy is the dcllnitivc investigation in kidney disorders and is particularly helpful in distinguishing steroid responsive ncphn>tic syndrome J"rom li>cal glomerulosclerosis. It is al\cndcd hy a small risk lor patients. Over the past three decades many attempts have been made to develop reliable non-invasive tests to predict underlying
kidney disorders and response to steroids.
Our study was done to evaluate the diagnostic value or urinary
level of retinol binding protein as an indicator li>r steroid response
Our study was carried out on i' patients suiTering ti•om NS attending the nephrology clinic in the Children Hospital, Cairo University. these patients were divided into two groups, the l(mnar gnJUp was steroid sensitive and the later group was steroid resistant. The study included also \ • healthy children with same age as a control group.
The results o(our studr showetl that:
Renal tubular markers as retinol binding protein can he used as sensitive diagnostic and prognostic tests in detection of steroid response.
It was found that RBI' is elevated in steroid reSIStant patients and low in steroid sensitive patients.
Other data
| Title | DIAGNOSTIC VALUE OF URINARY RETINOL BINDING PROTEIN IN CHILDHOOD NEPHROTIC SYNDROME | Other Titles | القيمة التشخيصية لنسبة البروتينات العالقة بالريتينول فى البول فى مرضى التورم النفروزى | Authors | NAHLA AHMED EL MARAKBY | Issue Date | 2001 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| نهلة احمد المراكبى.pdf | 1.18 MB | Adobe PDF | View/Open |
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