DOSIMETRIC IMPROVEMENT AND ITS CLINICAL IMPACT FOLLOWING 3D PLANNING OF BREAST IRRADIATION
Mohammed Ibrahim Mohammed El-Sayed;
Abstract
The present study included 67 female patients having early breast cancer (stage I and II). In this study, 61% of patients were <50 years of age, 85% underwent MRM and all of them received adjuvant systemic therapy.
The patients were randomized into group A (30 patients) where 2D plan was done and executed and group B (37 patients) where 2D and 3D plans were done and the 3D plan was executed.
Different dosimetric and clinical criteria m groups A&B were analyzed, tabulated and compared.
There was statistically significant difference between group B 2D plan, group B 3D plan regarding target dosimetric criteria such as volume maximum dose, volume llO%, volume 105%, dose homogeneity index (DHI), maximum and minimum doses, with significant increase of DHI and reduction of o er dosimetric criteria in group B 3D plan. There was statistically significant elevation in the percentage of significant dosimetric improvement (87.5% in patients who did CBS compared to 55.2% in those who did MRM) and in the mean dosimetric improvement occurred in patients underwent CBS (mean value of 65%) compared to those who underwent mastectomy (mean value of 41.5%) (p < 0.05).
The mean dose to the ipsilateral lung was 33.1±12.8 cGy and NTCP for radiation pneumonitis was 0.02 ± 0.024 in group B 2D plan compared to 20.6
±11.3 cGy and 0.01±0.016 respectively. The incidence of grade II radiation pneumonitis in our study was 6.7 % in group A 2D plan compared to 2.7 % in group B 3D plan. Our study showed grade I radiation induced cardiotoxicity in
23.5 % of patients in group A 2D plan and 27.8 % of patients in group B 3D
plan.
The patients were randomized into group A (30 patients) where 2D plan was done and executed and group B (37 patients) where 2D and 3D plans were done and the 3D plan was executed.
Different dosimetric and clinical criteria m groups A&B were analyzed, tabulated and compared.
There was statistically significant difference between group B 2D plan, group B 3D plan regarding target dosimetric criteria such as volume maximum dose, volume llO%, volume 105%, dose homogeneity index (DHI), maximum and minimum doses, with significant increase of DHI and reduction of o er dosimetric criteria in group B 3D plan. There was statistically significant elevation in the percentage of significant dosimetric improvement (87.5% in patients who did CBS compared to 55.2% in those who did MRM) and in the mean dosimetric improvement occurred in patients underwent CBS (mean value of 65%) compared to those who underwent mastectomy (mean value of 41.5%) (p < 0.05).
The mean dose to the ipsilateral lung was 33.1±12.8 cGy and NTCP for radiation pneumonitis was 0.02 ± 0.024 in group B 2D plan compared to 20.6
±11.3 cGy and 0.01±0.016 respectively. The incidence of grade II radiation pneumonitis in our study was 6.7 % in group A 2D plan compared to 2.7 % in group B 3D plan. Our study showed grade I radiation induced cardiotoxicity in
23.5 % of patients in group A 2D plan and 27.8 % of patients in group B 3D
plan.
Other data
| Title | DOSIMETRIC IMPROVEMENT AND ITS CLINICAL IMPACT FOLLOWING 3D PLANNING OF BREAST IRRADIATION | Other Titles | تحسن توزيع الجرعات الإشعاعية وتأثيره الإكلينيكي كنتيجة للتخطيط ثلاثي الأبعاد الإشعاعي لأورام الثدي | Authors | Mohammed Ibrahim Mohammed El-Sayed | Issue Date | 2004 |
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