The Use of Composite of Bone Marrow Concentrate and Alloplast in Reconstruction of Residual Surgical Defects: A Radiographic and Histological study

Abstract

With the widespread use of cellular therapy in medical practice, attention has been directed to the application of autologous bone marrow in the field of reconstruction. The use of bone marrow concentrate has become an increasingly popular alternative and adjunct in the treatment of bony defects, cartilaginous lesions, and tendinous injuries. The available literature regarding the use of BMC in different tissue repair is highly heterogeneous with regards to indications, concentrations and overall functional outcomes. Hence, this study attempts to examine the evidence behind the use of BMC as an alternative to autologous bone graft in the repair of bony defects. This study included two parts:

1- A clinical study

2- An experimental study

The clinical study was conducted on 14 residual surgical non- continuity defects resulting from enucleation of benign odontogenic/non- odontogenic cyst or tumour with low recurrence rate. Patients were divided into two groups:

• Group A (study group): included seven residual surgical non- continuity defects where grafting of the defects was done using a composite of bone marrow aspirate concentrate (BMAC) and an alloplastic scaffold. • Group B (control group): included seven residual surgical non- continuity defects where grafting of the residual surgical defects was done using autologous bone graft.

Radiographic evaluation was done using Cone beam C.T. scan at the