Pattern of Osteoporosis in Systemic Lupus Erythematosus patients
Soha El Dessouki Ibrahim Mohamed;
Abstract
Systemic osteoporosis is a common complication of SLE. Various factors such as, duration of the disease, dosage and duration of glucocorticoids are involved in the pathogenesis of osteoporosis in SLE.
Glucocorticoid therapy, amenorrhea (Rigotti et al,1991), hyperparathyroidism secondary to chronic renal failure (Babini et al,1988), conscious avoidance of sunshine, immobility as a result of arthritis, and the disease itself are the most likely contributing factors m osteoporosis associated with SLE (Formiga et al,J995).
Cytokines including interleukin 6, interleukin 1, and tumour necrosis factor a have direct actions on bone including the stimulation of bone resorption and bone formation (Mac Donald, 1992).
Dual energy X-ray absorbtiometry (DEXA) is an established technique for measuring axial and appendicular BMD to diagnose osteoporosis.
Our study included 30 premenopausal female patients with SLE. All the patients underwent clinical examination, laboratory examination and radiological investigations involving measurement of lumbar· spine, left femoral neck and left forearm BMD using DEXA.
Glucocorticoid therapy, amenorrhea (Rigotti et al,1991), hyperparathyroidism secondary to chronic renal failure (Babini et al,1988), conscious avoidance of sunshine, immobility as a result of arthritis, and the disease itself are the most likely contributing factors m osteoporosis associated with SLE (Formiga et al,J995).
Cytokines including interleukin 6, interleukin 1, and tumour necrosis factor a have direct actions on bone including the stimulation of bone resorption and bone formation (Mac Donald, 1992).
Dual energy X-ray absorbtiometry (DEXA) is an established technique for measuring axial and appendicular BMD to diagnose osteoporosis.
Our study included 30 premenopausal female patients with SLE. All the patients underwent clinical examination, laboratory examination and radiological investigations involving measurement of lumbar· spine, left femoral neck and left forearm BMD using DEXA.
Other data
| Title | Pattern of Osteoporosis in Systemic Lupus Erythematosus patients | Other Titles | انماط هشاشة العظام لمرض الذئبة الحمراء | Authors | Soha El Dessouki Ibrahim Mohamed | Issue Date | 2001 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| Soha El Dessouki Ibrahim Mohamed.pdf | 1.38 MB | Adobe PDF | View/Open |
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