EFFICACY OF INTRAVENOUS TRANEXAMIC ACID IN REDUCING BLOOD LOSS AFTER CESAREAN SECTION A RANDOMIZED CONTROLLED TRIAL
Mohamed Sayed Korany;
Abstract
SUMMARY
C
aesarean section (CS) rate has increased to as high as 25 to 30% in many areas of the world. Delivery by CS can cause more complications than normal vaginal delivery and one of the most complications is postpartum bleeding, which can be life threatening. To reduce maternal mortality and morbidity caused by bleeding, it’s important to reduce the extent of bleeding during and after CS.
To control the bleeding after CS, some medications such as oxytocin, prostaglandins (E1, E2, F2&) and methylergometrine have been used.
Oral misoprostol appears to be safe and as effective as intravenous oxytocin in reduction of intra-operative blood loss during CS under regional anaesthesia and merits further investigations.
General anaesthesia resulted in significantly more blood loss, lower postoperative haematocrit. Regional anaesthesia is a better choice for CS than general anaesthesia. However the availability of different techniques and ability to change the technique when needed were very useful and important.
Tranexamic acid is a synthetic molecule that exerts its antifibrinolytic action through the reversible blockade of the lysine binding site on plasminogen molecule.
Tranexamic acid has been routinely used for many years to reduce haemorrhage during and after surgical procedures, such as coronary bypass, scoliosis surgery and knee arthroplasty. It has been shown to be very useful for reducing blood loss and the need for blood transfusion. There are some reports on the use of tranexamic acid in prevention of blood loss in many gynecological diseases such as menorrhagia and CS.
C
aesarean section (CS) rate has increased to as high as 25 to 30% in many areas of the world. Delivery by CS can cause more complications than normal vaginal delivery and one of the most complications is postpartum bleeding, which can be life threatening. To reduce maternal mortality and morbidity caused by bleeding, it’s important to reduce the extent of bleeding during and after CS.
To control the bleeding after CS, some medications such as oxytocin, prostaglandins (E1, E2, F2&) and methylergometrine have been used.
Oral misoprostol appears to be safe and as effective as intravenous oxytocin in reduction of intra-operative blood loss during CS under regional anaesthesia and merits further investigations.
General anaesthesia resulted in significantly more blood loss, lower postoperative haematocrit. Regional anaesthesia is a better choice for CS than general anaesthesia. However the availability of different techniques and ability to change the technique when needed were very useful and important.
Tranexamic acid is a synthetic molecule that exerts its antifibrinolytic action through the reversible blockade of the lysine binding site on plasminogen molecule.
Tranexamic acid has been routinely used for many years to reduce haemorrhage during and after surgical procedures, such as coronary bypass, scoliosis surgery and knee arthroplasty. It has been shown to be very useful for reducing blood loss and the need for blood transfusion. There are some reports on the use of tranexamic acid in prevention of blood loss in many gynecological diseases such as menorrhagia and CS.
Other data
| Title | EFFICACY OF INTRAVENOUS TRANEXAMIC ACID IN REDUCING BLOOD LOSS AFTER CESAREAN SECTION A RANDOMIZED CONTROLLED TRIAL | Other Titles | تقييم تأثير حمض الترانيكساميك بالوريد علي فقدان الدم بعد الولادة القيصرية | Authors | Mohamed Sayed Korany | Issue Date | 2015 |
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