Effect of Sildenafil Citrate on Some Physiological and Hematological Parameters in Diabetic Male Albino Rats

Abstract

Mariam Saber Abd El-Kader El-Abassy M.Sc., Fac. Sci. Ain Shams Univ., Cairo, 2017 Effect of Sildenafil Citrate on Some Physiological and Hematological Parameters in Diabetic Male Albino Rats. Key words: Alloxan, Hyperglycemia, Hyperfibrinogenemia, Protein C, Protein S, Sildenafil citrate. Diabetes is a group of metabolic disorders characterized by a chronic hyperglycemic condition resulting from defects in insulin secretion, insulin action or both. Phosphodiesterase type 5 inhibitors (PDE5Is) like sildenafil citrate that blocks the degradative action of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells lining the blood vessels provide a novel therapeutic option for treating diabetes complications and improving the quality of life in diabetic patients, they acting by various mechanisms including nitric oxide (NO) donor effect and antioxidant effect. The purpose of this study is to evaluate the oral treatment effect of sildenafil on some biochemical and hematological parameters in alloxan-induced diabetes in male rats. Thirty-two adult male Wistar albino rats were divided randomly into II classes. Class I consists of two healthy groups: control group (not received any medication) and sildenafil-treated group (10 mg/kg body weight).