Assessment of serum Desnutrin levels in patients with acne vulgaris
Mohamed Abd El Hamid Habib;
Abstract
Acne vulgaris is a common inflammatory skin disease as a result of interplay between multiple factors including genetic, inflammatory mediators, follicular hyperkeratinization, Propionibacterium acnes follicular colonization and excess sebum production.
The main treatment of acne is either topical or systemic directed to the pathogenic factors involved in acne. Topical treatments include benzoyl peroxide, topical retinoids, topical antibiotics, salicylic acid, azelaic acid, lactic acid, tea tree oil, picolinic acid gel and dapsone gel. Combinations of multiple topical agents was found to be superior to single agent treatment. Systemic treatments include systemic antibiotics, hormonal agents and isotretinoin. Other modalities are intralesional steroid injections, comedone removal, superficial peels, phototherapy and fractional laser treatments.
Desnutrin is a triacylglycerol (TAG) lipase that belongs to the patatin-like domain-containing family of proteins, it is induced during a low nutritional state in mice. Desnutrin is highly expressed in adipose tissue but is also found at low levels in other tissues. Desnutrin’s excessive secretion from adipocytes results in decreased triacylglycerol storage and increased lipolysis, fatty acid oxidation and thermogenesis, these effects result in high energy expenditure and resistance to diet-related obesity development.
This study is a case-control study which included 40 patients with active acne lesions and 40 healthy subjects. The control group was composed of age, gender, and Body mass index (BMI) matched individuals.
Each individual was subjected to detailed history, general and dermatological examination, measurement of height, weight waist circumference, fasting blood glucose, triglycerides, LDL, VLD
The main treatment of acne is either topical or systemic directed to the pathogenic factors involved in acne. Topical treatments include benzoyl peroxide, topical retinoids, topical antibiotics, salicylic acid, azelaic acid, lactic acid, tea tree oil, picolinic acid gel and dapsone gel. Combinations of multiple topical agents was found to be superior to single agent treatment. Systemic treatments include systemic antibiotics, hormonal agents and isotretinoin. Other modalities are intralesional steroid injections, comedone removal, superficial peels, phototherapy and fractional laser treatments.
Desnutrin is a triacylglycerol (TAG) lipase that belongs to the patatin-like domain-containing family of proteins, it is induced during a low nutritional state in mice. Desnutrin is highly expressed in adipose tissue but is also found at low levels in other tissues. Desnutrin’s excessive secretion from adipocytes results in decreased triacylglycerol storage and increased lipolysis, fatty acid oxidation and thermogenesis, these effects result in high energy expenditure and resistance to diet-related obesity development.
This study is a case-control study which included 40 patients with active acne lesions and 40 healthy subjects. The control group was composed of age, gender, and Body mass index (BMI) matched individuals.
Each individual was subjected to detailed history, general and dermatological examination, measurement of height, weight waist circumference, fasting blood glucose, triglycerides, LDL, VLD
Other data
| Title | Assessment of serum Desnutrin levels in patients with acne vulgaris | Other Titles | تقييم مستوى ديسنيوترين في مصل مرضي حب الشباب | Authors | Mohamed Abd El Hamid Habib | Issue Date | 2017 |
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