Propofol Total Intravenous Anesthesia and its Effect on Serum Lipoproteins and Cardiac Enzymes

Abstract

Diisopropylphenol (Propofol) is an addition to the range of intravenous anesthetic agents which has been shown to be effective and safe for anesthesia in man. Propofol was solubilized previously in Cremophor EL, but nowadays it is prepared as an aqueous emulsion formulation.

Rapid speed of recovery and high quality of recovery are two of the most striking features which characterize anesthesia with propofol.

Propofol has several advantages; in particular, rapid uneventful recovery that makes total intravenous anesthesia (TIVA) with propofol suitable for day-case surgery and when rapid ambulation and early return to normal activities are indicated. This wcy{ was planned to be a cl al study of this intravenousr sthetic agent in attempt to evaluate its real place in anesthetic)'ractice.

Thirty patients of both sexes and of ASA class I and II were subjected to ophthalmic and E.N.T. surgeries. All patients did not receive any premedication in the preoperative period.

Patients received propofol 1 - 2 mglkg for induction followed by propofol infusion 150 J.tg/kg/min. which was reduced to 50 j..tg/kg/min. after thirty minutes of surgery. Atracurium (0.5 mg/kg) was used to induce muscle relaxation for both