Comparison between Haptoglobin and CA 125 to Predict the Nature of Ovarian Mass
Sheren Abd-El Wahab Hamed El-Saedy;
Abstract
Ovarian tumors can occur at any age in woman’s life but becoming increasingly malignant towards and after menopause.
Despite of the improved surgical techniques and effective chemotherapeutic regimens available for management of ovarian cancer, there is no improvement in its early detection. Thus ovarian cancer remains a leading cause of death from gynecological malignancies with an overall poor prognosis.
The identification of novel cancer biomarkers opens the possibility for early detection, better monitoring of tumour progression. Haptoglobin is a novel biomarker which was used in diagnosis of ovarian cancer.
The basic haptoglobin molecule is a tetrameric protein with two / dimmers. The -chains are identical in all haptoglobin types. It originates mainly from the liver, and elevation of this peptide could be observed in a manner similar to other acute phase proteins in infections, inflammations, and various malignant diseases, including lung and bladder cancers, leukemia, breast, cancer, malignant lymphoma, urogenital tumours and esophageal squamous cell carcinoma.
The aim of this study is to evaluate the performance of haptoglobin and CA125 to increase sensitivity and specificity in diagnosis of nature of ovarian mass. The study incorporated 60 women with ovarian mass scheduled for surgery. It comprised of 38 premenopausal and 22 postmenopausal women, they were subjected to careful history taking, clinical examination, ultrasound examination, preoperative assessment of serum level of haptoglobin and CA125.
It was found that age is a significant factor associated with malignancy (P < 0.001), where the mean age for benign cases was 37.7, while that for malignant cases was 50.1 years.
It was found that weight isn't significant factor as P value = 0.064.
The comparison showed that menopausal status was significantly different with (P < 0.001.
As for benign cases only (16.7%) were postmenopausal while for malignant cases (56.7%) were postmenopausal.
Malignancy more associated with mutliparity than nulliparity in this study with (P < 0.001).
Thirty seven patients had medical co-morbidities as hypertension and diabetes mellitus. Only 2 patients gave family history of breast cancer, no cases gave family history of ovarian cancer.
Symptoms as loss of appetite, loss of weight, abdominal bloating although less common were significantly associated with malignant cases with (P < 0.0001).
Although abdominal pain was the most common presenting symptoms experienced by 80% of patients, there was no significant difference between benign and malignant cases with (P = 0.168).
Ultrasound findings were significantlyassociated with malignancy, in which presence of solid areas were with p value (P < 0.0001), presence of ascites with P value (P < 0.0001.
Analysis of serum CA125 (U/ml) and haptoglobin (U/ml) in the study group showed significant difference between benign and malignant cases and between benign, malignant cases versus control.
Despite of the improved surgical techniques and effective chemotherapeutic regimens available for management of ovarian cancer, there is no improvement in its early detection. Thus ovarian cancer remains a leading cause of death from gynecological malignancies with an overall poor prognosis.
The identification of novel cancer biomarkers opens the possibility for early detection, better monitoring of tumour progression. Haptoglobin is a novel biomarker which was used in diagnosis of ovarian cancer.
The basic haptoglobin molecule is a tetrameric protein with two / dimmers. The -chains are identical in all haptoglobin types. It originates mainly from the liver, and elevation of this peptide could be observed in a manner similar to other acute phase proteins in infections, inflammations, and various malignant diseases, including lung and bladder cancers, leukemia, breast, cancer, malignant lymphoma, urogenital tumours and esophageal squamous cell carcinoma.
The aim of this study is to evaluate the performance of haptoglobin and CA125 to increase sensitivity and specificity in diagnosis of nature of ovarian mass. The study incorporated 60 women with ovarian mass scheduled for surgery. It comprised of 38 premenopausal and 22 postmenopausal women, they were subjected to careful history taking, clinical examination, ultrasound examination, preoperative assessment of serum level of haptoglobin and CA125.
It was found that age is a significant factor associated with malignancy (P < 0.001), where the mean age for benign cases was 37.7, while that for malignant cases was 50.1 years.
It was found that weight isn't significant factor as P value = 0.064.
The comparison showed that menopausal status was significantly different with (P < 0.001.
As for benign cases only (16.7%) were postmenopausal while for malignant cases (56.7%) were postmenopausal.
Malignancy more associated with mutliparity than nulliparity in this study with (P < 0.001).
Thirty seven patients had medical co-morbidities as hypertension and diabetes mellitus. Only 2 patients gave family history of breast cancer, no cases gave family history of ovarian cancer.
Symptoms as loss of appetite, loss of weight, abdominal bloating although less common were significantly associated with malignant cases with (P < 0.0001).
Although abdominal pain was the most common presenting symptoms experienced by 80% of patients, there was no significant difference between benign and malignant cases with (P = 0.168).
Ultrasound findings were significantlyassociated with malignancy, in which presence of solid areas were with p value (P < 0.0001), presence of ascites with P value (P < 0.0001.
Analysis of serum CA125 (U/ml) and haptoglobin (U/ml) in the study group showed significant difference between benign and malignant cases and between benign, malignant cases versus control.
Other data
| Title | Comparison between Haptoglobin and CA 125 to Predict the Nature of Ovarian Mass | Other Titles | مقارنة بين الهابتوجلوبين وسى إيه-125 كإحدى دلائل الأورام فى الكشف عن طبيعة أورام المبيض | Authors | Sheren Abd-El Wahab Hamed El-Saedy | Issue Date | 2014 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.