Role of Ascorbic Acid & Statin in reduction of the incidence of the Atrial Fibrillation in patients under B-blocker and undergoing Coronary Artery Bypass Graft Operation In Early Post-operative Period

Abstract

Atrial fibrillation (AF) is the most common sustained arrhythmia that is associated with significant morbidity and mortality. The incidence of postoperative atrial fibrillation (AF) is about 20% to 40 %.

It is associated with thrombo-embolic events, hemodynamic disorders and longer hospital stays Current available therapies remain inadequate in symptom control and secondary prevention and are often associated with significant side effects.

The mechanisms underlying the pathogenesis of AF are poorly understood, although electrophysiological remodeling has been described as an important initiating step. Recently, increasing evidence implicates oxidative stress and inflammation in the pathogenesis of AF. We searched the literature for evidence to support the use of statin &antioxidant vitamins C in combination with B-blocker to decrease the incidence of AF after CABG in early post operative period. These vitamins, through their reactive-oxygen-species- (ROS-) scavenging effect, have shown a role in AF prevention.