EFFECT OF CIS-RETINOIC ACID ON BCL-2 AND SOME MITOCHONDRIAL ENZYMES IN PATIENTS WITH ACUTE MYELOID LEUKEMIA
Lutfi Abdel Salam Abdelrab AI-Maktari;
Abstract
Complex pathways exist for the regulation of the cell cycle and apoptosis.. Abnormalities in' the expression or function of the key proteins in either of these regulatory pathways could confer proliferative advantage to leukemic cells and there by contribute to leukemogenesis.
Most antileukemic chemotherapeutic agents functions via induction of
.
apoptosis, consequently, sensitivity or resistance of leukemic blasts to chemotherapy may correlate with the apoptotic po•.-.ential of a cell.
In view of the interaction of the various proteins, the resistance induced by upregulation of BCL-2 protein and other antiapoptotic
'
family members might be reversed by their specific.down-regulation.
13-cis RA has been used in the treatment of juvenile chronic myelogenous leukaemia and adult myelodysplastic syndromes and
•: '
AML, and are now used m the first-line treatment of acute promyelocytic leukemia( APL) a subtype of acute • myeloblastic leukaemia (AML). Retioids represents one class of compounds which reverse the progression of malignant disease . It have also been found
to be effective in inhibiting AML cell growth and inducing apoptosis.
Most antileukemic chemotherapeutic agents functions via induction of
.
apoptosis, consequently, sensitivity or resistance of leukemic blasts to chemotherapy may correlate with the apoptotic po•.-.ential of a cell.
In view of the interaction of the various proteins, the resistance induced by upregulation of BCL-2 protein and other antiapoptotic
'
family members might be reversed by their specific.down-regulation.
13-cis RA has been used in the treatment of juvenile chronic myelogenous leukaemia and adult myelodysplastic syndromes and
•: '
AML, and are now used m the first-line treatment of acute promyelocytic leukemia( APL) a subtype of acute • myeloblastic leukaemia (AML). Retioids represents one class of compounds which reverse the progression of malignant disease . It have also been found
to be effective in inhibiting AML cell growth and inducing apoptosis.
Other data
| Title | EFFECT OF CIS-RETINOIC ACID ON BCL-2 AND SOME MITOCHONDRIAL ENZYMES IN PATIENTS WITH ACUTE MYELOID LEUKEMIA | Other Titles | تأثير عقار الرواكوتان على بى- سى- ال-2 وبعض انزيمات الميتوكوندريا فى مرصى سرطان الدم النقوى الحاد | Authors | Lutfi Abdel Salam Abdelrab AI-Maktari | Issue Date | 2003 |
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