Possible modulatory effect of resveratrol on methotrexate efficacy and pharmacokinetics in a model of experimentally induced arthritis

Abstract

Background: Low dose methotrexate is the cornerstone of rheumatoid arthritis treatment. However, it is seldom used alone and almost usually combined with other anti-rheumatic agents which increases the risk of toxicity. Objective: The present study aimed to investigate the modulatory effect of resveratrol on the efficacy of methotrexate, in addition to elucidating the possible mechanisms for this modulatory effect, and also testing the effect of nano-encapsulation of resveratrol on improving this modulatory effect. Methods: Complete Freund's adjuvant was used to induce arthritis. Arthritic rats were treated with methotrexate and resveratrol (solution)/resveratrol nano-emulsion. Arthritic score, gait score, ankle diameter, paw volume and histopathology were determined to assess the anti-arthritic effects.