The Effect of Captopril on Experimentally Induced Benign Prostatic Hyperplasia
Fatma Mostafa Zaki Mostafa;
Abstract
This study was conducted to investigate the potential protective effect of captopril against testosterone-induced benign prostatic hyperplasia in rats and elucidate the underlying molecular mechanisms.
Experimental design:
1) Screening study
To select the most effective dose of Cap. In this study, rats were divided into 5 groups and treated for 5 consecutive days per week for 4 successive weeks:
-Group 1: animals in this group served as the control and were given vehicles only.
-Group 2: animals in this group served as the BPH model and were injected with testosterone (3 mg/kg) subcutaneously.
-Groups 3, 4 and 5: animals in these groups were given Cap at doses of (25, 50 and 100 mg/kg) respectively, dissolved in saline orally 1hr prior to testosterone injection.
Assessed parameters:
- Prostate weight
- Prostatic index (Prostate weight/ Body weight ratio)
- PAP
- PSA
- Histological examination (H&E)
This study revealed that Cap (100 mg/kg) is the most effective dose since it significantly decreased the prostate weight, prostatic index
Experimental design:
1) Screening study
To select the most effective dose of Cap. In this study, rats were divided into 5 groups and treated for 5 consecutive days per week for 4 successive weeks:
-Group 1: animals in this group served as the control and were given vehicles only.
-Group 2: animals in this group served as the BPH model and were injected with testosterone (3 mg/kg) subcutaneously.
-Groups 3, 4 and 5: animals in these groups were given Cap at doses of (25, 50 and 100 mg/kg) respectively, dissolved in saline orally 1hr prior to testosterone injection.
Assessed parameters:
- Prostate weight
- Prostatic index (Prostate weight/ Body weight ratio)
- PAP
- PSA
- Histological examination (H&E)
This study revealed that Cap (100 mg/kg) is the most effective dose since it significantly decreased the prostate weight, prostatic index
Other data
| Title | The Effect of Captopril on Experimentally Induced Benign Prostatic Hyperplasia | Other Titles | "تأثير الكابتوبريل على تضخم البروستاتا الحميد المحدث تجريبيا" | Authors | Fatma Mostafa Zaki Mostafa | Issue Date | 2017 |
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