Association between Serum Testosterone and Vitamin D and Calcium Supplementation in Women with Polycystic Ovary Syndrome

Abstract

P olycysticovarysyndrome(PCOS)isthemostcommonendocrinedisorderofreproductive-agedwomen.Itischaracterizedbyandrogenexcess,chronicoligoanovulationandpolycysticovaries(PCO)onultrasound. Womenwithpolycysticovarysyndrome(PCOS)frequentlysufferfrommetabolicdisturbances,inparticularfrominsulinresistance.AccumulatingevidencesuggeststhatvitaminDdeficiencymaycontributetothedevelopmentofinsulinresistance.Hence,weaimedtoexaminetheeffectofvitaminDsupplementationonmetabolicandendocrineparametersinPCOSwomen. Objective: ToassesseffectsofdailyvitaminD3andcalciumsupplementationfor3monthsontotaltestosteronelevelinwomenwithpolycysticovarysyndrome. Patientandmethods: 2GroupsofWomencomplainingofPCOsandinfertility.Group1receivedVitaminD3800IUandCa1000mg)(Ostovaltablets)treatmentfor3months(thisdosetoavoidtoxicityandsideeffectsofotherhighdoses)besidemetformin1500mgperday,Group2receivedmetformin1500mgperdayonlyallarediagnosedandhavealltheinclusionandexclusioncriteria,allcasesrecruitedfromoutpatientgynecologyclinicsatAinShamsUniversityMaternityhospitalafterthepurposeofthestudyisclearlyexplainedandconsentisobtainedfromallwomenenrolledinthestudyalongwithroutineconsentasgovernedbythehospitalrules,Patientswerefollowedupatfirstand3monthslaterforevaluatingtotaltestosteronelevelandinsulinresistancetest(HOMA)(fastinginsulinandfastingglucose).