Study of Serum Retinol Binding Protein 4 and its Association with Insulin Resistance in HCV Patients
Enas AbdelMajed Youssef;
Abstract
Hepatitis c virus HCV infection is one of the principle causes of cirrhosis and hepatocellular carcinoma and has a strong impact on public health worldwide.
A part from its hepatotropic characteristics,HCV infection carries a significant pathogenic effect for the devolpment of insulin resistance IR and for subsequent type 2 diabetes mellitus DM (Shintani eta/., 2004, Zien et a/.,2005 & Huang et a/., 2008). Previous studies showed that 37.8% of chronic HCV infection CHC patients had DM. IR may undermine the treatment response to antiviral therapy and the disease progression of HCV (Romero Gomez et a/., 2005). Therefore,measurement of IR appears to be a feasible method for disease outcome assessment in patients with HCV infection.
Recently attention has been paid to the role of retinol - binding protein 4 RBP4 in the pathogenesis of IR. This protein,a member of the lipocalin family (Van Dam et al.,
2007) is secreted mainly by hepatocytes 80%,but also by
adipose tissue 20%.
There is a clinical evidence that circulating RBP4 levels are related to the severity of IR and to the various features of the metabolic syndrome (Lee eta/., 2007).
A part from its hepatotropic characteristics,HCV infection carries a significant pathogenic effect for the devolpment of insulin resistance IR and for subsequent type 2 diabetes mellitus DM (Shintani eta/., 2004, Zien et a/.,2005 & Huang et a/., 2008). Previous studies showed that 37.8% of chronic HCV infection CHC patients had DM. IR may undermine the treatment response to antiviral therapy and the disease progression of HCV (Romero Gomez et a/., 2005). Therefore,measurement of IR appears to be a feasible method for disease outcome assessment in patients with HCV infection.
Recently attention has been paid to the role of retinol - binding protein 4 RBP4 in the pathogenesis of IR. This protein,a member of the lipocalin family (Van Dam et al.,
2007) is secreted mainly by hepatocytes 80%,but also by
adipose tissue 20%.
There is a clinical evidence that circulating RBP4 levels are related to the severity of IR and to the various features of the metabolic syndrome (Lee eta/., 2007).
Other data
| Title | Study of Serum Retinol Binding Protein 4 and its Association with Insulin Resistance in HCV Patients | Other Titles | دراسة البروتين 4 المرتبط بالرتينول وعلاقته بمقاومة الأنسولين فى المرضى المصابين بالتهاب الكبدى ج | Authors | Enas AbdelMajed Youssef | Issue Date | 2011 |
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