BONE REMODELING

Abstract

After initial ossification of embryonic skeleton osteoclast and osteoblast begin modeling and remodeling each bone. The • rate of tuniover of skeleton approaches 100% per year 111 the first year of life, decline to about

I 0% per year 111 late childhood and then usually continues approximately this rate or more throughout life.In •modeling, bone resorption or formation at a particular site occur independently of one another; in remodeling, resorption and formation occur in a coupled

sequence..New specific been developed that formation (plasma level phosphatase) or bone

markers of bone remodeling allow the evaluation of of osteocalcin and bone resorption (collagen . cross-link

have bone alkaline levels

m urine). These markers can be used to evaluate bone disease.