Effects of Coenzyme Q10 on Amiodarone-Induced Lung Toxicity in Adult and Senile Male albino Rats
Marian Mokhtar Shokry;
Abstract
The present work investigated the toxic effects of amiodarone, an antiarrhythmic agent, on the lung structure of both adult and senile male albino rats and the possible protective role of coenzyme Q10, an antioxidant agent, against amiodarone toxicity.
Forty eight male albino rats, twenty four adult and twenty four senile, were used in the present study. Animals were divided into six groups. Group I consisted of twelve adult control rats and subdivided into three subgroups; the first received no treatment, the second received 1 ml of olive oil (vehicle of coenzyme Q10) by gastric tube, the third received 3.5 ml of coenzyme Q10 dissolved in olive oil by gastric tube. Group II consisted of twelve senile control rats and was further subdivided into three subgroups; the first received no treatment, the second received 1 ml of olive oil (vehicle of coenzyme Q10) by nasogastric tube, the third received 5.5 ml of coenzyme Q10 dissolved in olive oil by gastric tube. Group III Consisted of six adult rats that received 0.35 ml of amiodarone by intraperitoneal injection. Group IV consisted of six senile rats that received 0.55 ml of Amiodarone ampoule by intraperitoneal injection. Group V consisted of six adult rats that received 0.35 ml amiodarone by intraperitoneal injection concomitant with 3.5 ml coenzyme Q10 in olive oil by
Forty eight male albino rats, twenty four adult and twenty four senile, were used in the present study. Animals were divided into six groups. Group I consisted of twelve adult control rats and subdivided into three subgroups; the first received no treatment, the second received 1 ml of olive oil (vehicle of coenzyme Q10) by gastric tube, the third received 3.5 ml of coenzyme Q10 dissolved in olive oil by gastric tube. Group II consisted of twelve senile control rats and was further subdivided into three subgroups; the first received no treatment, the second received 1 ml of olive oil (vehicle of coenzyme Q10) by nasogastric tube, the third received 5.5 ml of coenzyme Q10 dissolved in olive oil by gastric tube. Group III Consisted of six adult rats that received 0.35 ml of amiodarone by intraperitoneal injection. Group IV consisted of six senile rats that received 0.55 ml of Amiodarone ampoule by intraperitoneal injection. Group V consisted of six adult rats that received 0.35 ml amiodarone by intraperitoneal injection concomitant with 3.5 ml coenzyme Q10 in olive oil by
Other data
| Title | Effects of Coenzyme Q10 on Amiodarone-Induced Lung Toxicity in Adult and Senile Male albino Rats | Other Titles | تأثير مساعد الانزيم Q10 علي تسمم الرئة الناتج عن الأميودارون في ذكور الجرذان البيضاء البالغة والمسنة | Authors | Marian Mokhtar Shokry | Issue Date | 2017 |
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