FORMULATION AND EVALUATION OF NADOLOL AS ANTIGLAUCOMA DRUG FOR TOPICAL APPLICATION

Abstract

Ophthalmic medications are sterile, isotonic preparations, usually introduced into the eye by placing them in contact with conjunctiva and cornea. This is usually accomplished by introducing the vehicle into the upper or lower cul-de-sac or directly onto the surface of the cornea. Topical applications of drugs to the eye is the most frequently employed route of administration for the treatment of various eye diseases. Among these diseases is glaucoma which have been reported to be a major cause • of visual loss. Microemulsions are receiving, through the years, increased attention as potential drug delivery systems. This attention is reflected in the great number of contributions handling the kinetics of drug release from these systems.

The rational of the present work is to formulate the drug in a new type of dosage form such as microemulsion, this was our way and method to increase its contact to the cornea, giving longer time of drug contact to the eye and slow possible release from the preparation.

Systematic studies addressing the different design and foni:mlation parameters in a microemulsion in-vivo performance are still awaited. The present thesis is a contribution aimed at the proper understanding of design-performance or formulation-performance relation ship m a microemulsion.