Comparison of Cholylglycine and Conventional Liver Function Tests to Study the Effect of Prolonged and Repeated Halothane and lsoflurane on Liver Functionb

Nabila Nasr Ibrahim


Halothane being as widely used in Egypt is a subject of renewed controversy. It has long been implicated as a possible cause of hepatitis in rare and sporadic cases. Hepatic dysfunction after halothane administration is of two types, mild and -severe. The mild type, in which there is slight elevation in li\'er enzymes without clinical manifestations, occurs in t\\ o phases. Phase I, occuning immediately postoperative, and phase II, starts to occur 24 hours after operation. The severe type in which there is fulminant hepatitis is very rare and has an incidence of I in 70,000. The possible mechanisms underlying hepatotoxicity are either formation of toxic intermediates, immunologic response in the form of antigen antibody reaction, or halothane acting as a hapten changing the antigenicity of the liver itself. Isoflurane IS chemically stable, with minimal biotransformation was claimed to have less hepatotoxic effects and minimal cardiovascular adverse effects. All conventional liver function tests including the enzymes: Aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase, lack specificity and sensitivity. Therefore, most previous studies on hepatotoxicity after administration of inhalational anesthetics should be considered non-specific.

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Other Titles دراسة مقارنة بين الكوليلجليسين ووظائف الكبد التقليدية لتقييم تأثير التعرض الطويل والمتكرر للهالوثين والأيزوفلورين على وظائف الكبد
Issue Date 2000

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