Musculo-Cutaneous changes in acute arterial and venous Insufficiency

Abstract

Experimental arterial and venous occlusion have been done in twenty dogs (ten arterial and ten venous) with the use of five dogs as a control group. The aim was to find out the histological changes in skeletal muscle and skin in each experimental group as an attempt to reach a reasonable explanation for persistence of some clinical symptoms especially after properly managed acute venous occlusion. In venous occlusion group, atrophy of type II muscle fibers, increased muscular fibrosis, and cutaneous cellular infiltration have been observed, while in arterial occlusion group atrophy of type II muscle fibers, hypertrophy of type I muscle fibers, less fibrous tissue proliferation in the . muscle and absence of cutaneous cellular infiltration have been proved. The histological differences between the two experimental groups could be claimed for persistence of some clinical symptoms after venous correctable occlusion rather than arterial one.