α1-acid glycoptotein for the early diagnosis of neonatal sepsis

Abstract

A variety of diagnostic infection markers were studied in years, no treatment or delaying the treatment of bacteremic infant leads to increase in mortality while starting antibiotic therapy to every infant in the presence of clinical suspicion causes antibiotic overuse and nosocomial infections because of unnecessary hospitalization.therefore, search for diagnostic markers of infection with high sensitivity and specificity is still required. This study included 30 neonates with the symptoms and signs of sepsis admitted to NICU in Ain Shams university pediatric hospital, and 30 neonates as control group. Respiratory distress was the common clinical finding followed by weak suckling, weak moro, abdominal distention, and feeding intolerance. In this study: Staphylococcus aureus is the most frequent type of bacteria isolated from the study group followed by E Coli, Klebsiella and pseudomonas. Hemoglobin level and WBCS count was highly significant different between the study group and patients group. Thrombocytopenia showed no statistical different between the two groups. The CRP level was found to be highly statistical different between the two groups. In this study, cut off point of CRP was 6mg/ml. the sensitivity of CRP in the first test was 76.67% in the second test 93.33%, the specificity was 90%, PPV 88.46% in the first test and 90.32% in the second.NPV was 79, 41% in the first test 93.10% in the second test. The α1AGP level found to be statistically significant between the study and the control group.