Silver Nanoparticles Effect on Antimicrobial and Antifungal Activity of New Heterocycles
ismail, mansoura;
Abstract
In this study 1-[4-(2-methoxy benzyl)-6-aryl-pyridazin-3(2H)-ylidene] hydrazines were used for the synthesis of new
heterocyclic systems such as thiazolidine, phthalazine, pyrazolo, tetrazolo, hydrazide and new pyridazine derivatives
to explore the effect of silver nanoparticles on their biological activity efficiency. Structures of the new heterocycles
were characterized by the aid of several analytical techniques including; 1H-NMR, FTIR and mass spectra. Silver
nanoparticles were synthesized by a simple methodology and the formation of silver nanoparticles was confirmed by
transmission electron microscopy (TEM) and UV studies. Most of the new prepared heterocycles were evaluated in
vitro as new antimicrobial agents. Combination effects of the silver nanoparticles on the antimicrobial activity of the
new heterocycles were investigated using the disk diffusion method. Compound 10a exhibited the strongest enhancing
effect of silver nanoparticles solution against Aspergillus flavus and Candida albicans.
heterocyclic systems such as thiazolidine, phthalazine, pyrazolo, tetrazolo, hydrazide and new pyridazine derivatives
to explore the effect of silver nanoparticles on their biological activity efficiency. Structures of the new heterocycles
were characterized by the aid of several analytical techniques including; 1H-NMR, FTIR and mass spectra. Silver
nanoparticles were synthesized by a simple methodology and the formation of silver nanoparticles was confirmed by
transmission electron microscopy (TEM) and UV studies. Most of the new prepared heterocycles were evaluated in
vitro as new antimicrobial agents. Combination effects of the silver nanoparticles on the antimicrobial activity of the
new heterocycles were investigated using the disk diffusion method. Compound 10a exhibited the strongest enhancing
effect of silver nanoparticles solution against Aspergillus flavus and Candida albicans.
Other data
| Title | Silver Nanoparticles Effect on Antimicrobial and Antifungal Activity of New Heterocycles | Authors | ismail, mansoura | Keywords | Silver nanoparticles, Pyridazine, Antimicrobial, Antifungal and (TEM) | Issue Date | 16-Sep-2010 | Journal | Bull. Korean Chem. Soc. | Description | In this study 1-[4-(2-methoxy benzyl)-6-aryl-pyridazin-3(2H)-ylidene] hydrazines were used for the synthesis of new heterocyclic systems such as thiazolidine, phthalazine, pyrazolo, tetrazolo, hydrazide and new pyridazine derivatives to explore the effect of silver nanoparticles on their biological activity efficiency. Structures of the new heterocycles were characterized by the aid of several analytical techniques including; 1H-NMR, FTIR and mass spectra. Silver nanoparticles were synthesized by a simple methodology and the formation of silver nanoparticles was confirmed by transmission electron microscopy (TEM) and UV studies. Most of the new prepared heterocycles were evaluated in vitro as new antimicrobial agents. Combination effects of the silver nanoparticles on the antimicrobial activity of the new heterocycles were investigated using the disk diffusion method. Compound 10a exhibited the strongest enhancing effect of silver nanoparticles solution against Aspergillus flavus and Candida albicans. |
DOI | 10.5012/bkcs.2010.31.12.3530 |
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