nephroprotection of lacidipine against gentamycin-induced nephrotoxicity in albino ratsShams El Dine, Sahar
AbstractAim: Gentamycin, a widely-used aminoglycoside antibiotic, is recognized as possessing significant nephrotoxic potential in human beings. Gentamycin-induced nephrotoxicity is suggested to be mediated via reactive oxygen species. The present study investigated the possible antioxidant nephroprotective effect of lacidipine as a calcium-channel blocker in a gentamycin-induced nephrotoxicity model in albino rats. Methods: Albino rats were divided into 3 groups. Group 1 received normal saline. Group 2 received gentamycin 80 mg/kg intraperitoneally for 14 days. Group 3 received lacidipine 1 mg/kg intraperitoneally 3 days before and 14 days concurrently with gentamycin. This dose does not affect the blood pressure of rats, as evidenced in the pilot study. Results: Gentamycin-induced nephrotoxicity was evidenced by a marked reduction in creatinine clearance. Treatment with lacidipine improved creatinine clearance compared to the gentamycin-treated group. In addition, it reduced thiobarbituric acid reactive substance, as an index of lipid peroxidation, with significant increases in superoxide dismutase enzyme in erythrocyte lysates and kidney catalase enzyme activities. Conclusion: This study recommends the use of lacidipine in prophylaxis against gentamycininduced nephrotoxicity.
|Keywords||lacidipine, gentamycin, nephrotoxicity, antioxidant, albino rats||Issue Date||3-Jun-2010||Publisher||Dovepress||Journal||Journal of Experimental Pharmacology||URI||http://research.asu.edu.eg/123456789/118|
Recommend this item
|JEP-10978-nephroprotection-of-lacidipine-against-gentamycin-induced-ne_060310.pdf||171.41 kB||Adobe PDF||View/Open|
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.