Folic acid diminishes the liver damages Induced in Aluminum Treated Rats and Their Fetuses.

El-Dakdoky, Mai H. 


Folic acid was investigated for its ability to prevent or alleviate aluminum-induced hepatotoxicity in pregnant rats and their fetuses. Pregnant rats were treated orally with aluminum chloride alone (100 mg/kg bwt) or aluminum chloride together with folic acid (20 mg/kg bwt) from the 1st to the 19th day of gestation. Folic acid supplementation appeared to counteract the aluminum related significant decrease in maternal body weight gain and increase in the relative liver weight. Also, treatment with folic acid showed improvement in the liver functions of pregnant rats; where serum alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase were increased under the effect of aluminum while serum total protein was significantly reduced. Furthermore, aluminum induced histological alterations of the maternal and fetal livers were ameliorated after folic acid administration. Folic acid has beneficial effects and can diminish the hepatic damages observed due to aluminum in mothers and fetuses.

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Keywords Aluminum; Fetotoxicity; Folic acid; Histopatholgy; Liver Function.
Issue Date 2010
Publisher The Egyptian society of basic medical sciences
Journal The Egyptian Journal of Medical Sciences. 
ISSN 1110-0540

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