CT perfusion in hepatocellular carcinoma: Is it reliable?

shalaby, mennatallah ; Ali Shehata K. 


Abstract


© 2017 Background: Ninety percent of hepatic cancers are hepatocellular carcinomas (HCC) which have an unfavorable prognosis. HCC is a hypervascular tumor supplied mainly by the hepatic artery. It has a higher blood supply than the surrounding hepatic tissue due to neovascularization. Computed tomography with perfusion imaging (CTP) is a non invasive tool which quantifies the blood flow parameters of HCC and compares it to the surrounding tissue. Purpose: To prove that CTP is a valuable diagnostic tool in diagnosis of HCC and posttherapeutic assessment. Patients and methods: One hundred and twenty-six HCC patients with 150 focal lesions are enrolled this study. Perfusion parameters are quantified and results are compared to those of triphasic CT. Results: CTP detected 141 lesions with 94% sensitivity and 40% specificity with elevated arterial perfusion (AP) and perfusion index (PI) with low portal flow (PF). It missed 5 lesions because of their hypovascularity and 4 lesions following radiofrequency ablation (RFA) and trans arterial chemo embolization (TACE). Conclusion: CTP is a safe and specific imaging tool for diagnosis and assessment of therapeutic interventional procedures in HCC.


Other data

Issue Date 1-Dec-2017
Journal Egyptian Journal of Radiology and Nuclear Medicine 
URI http://research.asu.edu.eg/123456789/144
DOI 4
791
http://api.elsevier.com/content/abstract/scopus_id/85037612034
48
10.1016/j.ejrnm.2017.07.013


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