Influence of some micronutrients and Citharexylum quandrangular extract against liver fibrosis in Schistosoma mansoni infected mice

Shadia M. Kadry; Mohamed , M. Azza; Farrag , M. Ebtehal; Fayed , B. Dalia; Kadry, shadia;

Abstract


Despite effective chemotherapy, schistosomiasis remains the second major public health problem in the developing world, second to malaria. The present study was undertaken to explore the therapeutic effect of the micronutrients (vitamin E and selenium) and chloroform extract ofCitharexylum quadrangular leaves and their mixture against the deleterious pathological impacts induced in mice livers by Schistosoma mansoni infection. Parasitological markers showed that oral ingestion of the different supplements to S. mansoni infected mice was effective in reducing the worm burden with concomitant decrease in the egg burden, granuloma count and its diameter as well as total area of infection in their livers versus untreated ones. Parasitological parameters were reflected by the improvement of the histopathological pictures of livers of infected-treated mice. The current investigation also showed that the used agents and their mixture successfully modulated liver fibrosis of infected mice which was documented by a marked decrease of liver hydroxyproline level ( as biomarker of liver fibrosis) as well as the serum levels of inflammatory fibrogenic mediators namely, fructosamine, tumor necrosis factor alpha (TNFα) and total immunoglobin E (IgE). In addition, the used agents showed ameliorative action on the elevated liver oxidative stress- nitric oxide (NO) and malondialdehyde (MDA) and the decreased antioxidant biomarkers, reduced glutathione (GSH), glutathione reductase (GR), thioredoxin reductase (TrxR) and catalase (CAT) which may have a role in liver damage and fibrosis due to S mansoni infection. In conclusion, treatment with the used micronutrients and plant extract either alone or in combination attenuated the deleterious impacts of S. mansoni infection on mice livers. The combination of all supplements was more effective as it greatly modified the inflammatory mediators and oxidative stress responsible for schistosomal liver fibrosis.


Other data

Title Influence of some micronutrients and Citharexylum quandrangular extract against liver fibrosis in Schistosoma mansoni infected mice
Authors Shadia M. Kadry ; Mohamed , M. Azza ; Farrag , M. Ebtehal ; Fayed , B. Dalia ; Kadry, shadia 
Keywords Citharexylum quadrangular;Vitamin E;Selenium;Shistosoma mansoni;Antioxidants
Issue Date 15-Oct-2013
Publisher ACADEMIC JOURNALS
Journal African Journal of Pharmacy and Pharmacology 
Volume 7
Issue 38
Start page 2628
End page 2638
ISSN 1996-0816
DOI 10.5897/AJPP12.620

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