Effect of Olive and Flaxseed Oils on the Amelioration of Serum Leptin , Adeponectin Levels ,Glucose Tolerance and Lipids Profile in Rats Fed on High Sucrose Diet

Abstract

The aim of the present study was to investigate how dietary olive oil a rich source of monounsaturated fatty acids and flaxseed oil a rich source of omega-3 fatty acids modulate the rat metabolic responses to high sucrose diet . Male albino rats weighing 150-180g were fed standard control diet or high sucrose diet (HSD) contain (35%) sucrose or HSD containing either olive oil or flax seed oil (4%) for 8 weeks. High sucrose diet intake led to higher food intake and body weight , hyperglycemia , impaired glucose tolerance test (GTT) , hyperliptinemia , hyperadeponectinemia as well as increase of total cholesterol (TC) and triacylglycerols (TAG) in serum and liver, with elevation of serum low density lipoprotein - cholesterol( LDL-C) and reduction in high density lipoprotein - cholesterol (HDL-C) . Olive and flax seed oils supplementation modulated serum glucose , leptin , adeponectin , improved GTT and reduced lipids profile parameters in serum and liver. In conclusion : Dietary olive and flaxseed oils caused an amelioration of metabolic alterations observed in HSD feeding rats.