Lead reproductive toxicity and modulator role of mango wastes extracts in mice

Abstract

Lead is an environmental metal known as reproductive toxicant. Mango wastes are a good source of potential antioxidants. The current study was carried out to examine the modulatory role of mango peel (MPE) and kernel (MKE) extracts against lead productive toxicity in mice. The following endpoints were studied: sperm DNA damage, histopathological changes in testes as well as male–mediated toxicity in non-treated female mice mated with Pb-acetate-treated males and their offspring. Two doses of MPE and MKE (50 and 100 mg/kg) were used to examine the mango extract effects on the reproductive toxicity induced by Pb-acetate (500 ppm). The mango extracts significantly decreased the level of sperm DNA damage induced by Pb-acetate, modulated the histopathological alterations stimulated in the testes by Pb-acetate exposure. The mango extracts also diminished the developmental toxicity induced in females mated with Pbacetate- treated males. It can be concluded that MPE and MKE have a modulator role against the lead reproductive toxicity in mice